In 1950, ASPIRIN is listed in the Guinness Book of Records as an analgesic with the highest volume of sales. In 1969 the packaging with the drug was part of the kits American astronaut Neil Armstrong on board the spacecraft "Apollo 11", which went on the Moon (" Store ").
What is the history of all known this medicine?
... Healing properties of willow were already well known to the ancient Sumerians and Egyptians. In European medicine powder white willow bark as a remedy for fever was introduced the "father of medicine" Hippocrates in the fifth century BC. In the mid-18th century, it drew the attention of the British. Made it out of the church by the name of Oxfordshire Stone, who began clinical trials, and June 2, 1763, speaking before the Royal Society, he is a very good case to use the infusion of willow bark for diseases accompanied by fever. ( plant world ).
... In 1850, from willow bark (in Latin "salix") was derived salicylic acid, which has a strong enough antifebrile action. However, since it derived from the bark of willow should not cheap, and it sought a replacement. And they found. It was found that salicylic acid in many other plant-bush - Spiro (Spirea salicifolia). Unfortunately, salicylic acid has a strong irritant and oral is not very good.
After joining the acetyl salicylic acid (acetic) radical happened long sought a medicine that oblodalo medicinal properties, but did not cause any negative side effects. The name of the new drug formed by taking from acetyl prefix "a-" and the root of the spirea "-spir-" received "a spirit-in." ( "The most famous medicine. Oh, that aspirin" journal "Science and Life" №3, 2015)
Extensive clinical use of aspirin was only after the salicylic acid from phenol to obtain steel, allowing to adjust its industrial production. This happened in 1893, although the substance - acetylsalicylic acid - was discovered 40 years earlier.
It aspirin, made over 100 years ago by Bayer, was the founder of a new era of drug - drugs made entirely of chemical raw materials.
All who are interested in this topic, I invite to discussion. The comments suggest to gather additional information about the history of aspirin, new drugs based on it. Do not forget about the references to sources of information.
Dear participants of the project! I invite you to solve problems in chemistry, which are based on the materials of the project. Terms of tasks can offer their copyrights (specify it), taken from the Internet (a link to the source) or from published sources - books, magazine (a link to the source).
I propose to solve the problem:
1) In 1904, the Russian military doctor Filonchikov put into practice the 5% alcoholic solution of iodine for the treatment of wounds. What weight crystalline iodine and alcohol which volume (density 0.8 g / ml) should be used to prepare 250 g of this solution?
2) Ammonia (10% solution of ammonia - NH 3) is used in surgical practice for the treatment of Hand Surgery. To this end, 25 ml of ammonia (density 0.96 g / ml) dissolved in 5 liters of warm water boiled. What is the mass fraction of ammonia in the resulting solution?